Known As:Beta-Nerve Growth Factor; Beta-NGF; NGF; NGFB;β-NGF

 PROPERTIES

Description:Recombinant Human Beta-Nerve Growth Factor is produced by our Mammalian

expression system and the target gene encoding Ser122-Arg239 is expressed

Accession:P01138

Formulation:Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.0.

Size:10µg/50µg/500µg/1mg

Purity:> 95%

Endotoxin:< 1 EU/µg as determined by LAL test.

Predicted Mol Mass:13.3 KDa

Apparent Mol Mass:14 KDa, reducing conditions

Reconstitution:Always centrifuge tubes before opening.Do not mix by vortex or pipetting.

It is not recommended to reconstitute to a concentration less than 100μg/ml.

Dissolve the lyophilized protein in distilled water.

Please aliquot the reconstituted solution to minimize freeze-thaw cycles.  

Shipping:The product is shipped at ambient temperature.

Upon receipt, store it immediately at the temperature listed below.

Storage:Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.

Reconstituted protein solution can be stored at 2-8°C for 2-7 days.

Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

Background:Human β-Nerve Growth Factor (β-NGF) was initially isolated in the mouse

submandibular gland. It is composed of three non-covalently linked subunits α, β, and γ; it exhibits all the biological activities ascribed to NGF. It is structurally related to BDNF, NT-3 and NT-4 and belongs to the cysteine-knot family of growth factors that assume stable dimeric structures. Β-NGF is a neurotrophic factor that signals through its receptor β-NGF, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. Β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. These results suggest that β-NGF is a pleiotropic cytokine, which in addition to its neurotropic activities may have an important role in the regulation of the immune system. Human β-NGF shares 90% sequence similarity with mouse protein and shows cross-species reactivity.

NOTE:The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.