Known As:Growth/differentiation factor 11; GDF-11; Bone morphogenetic protein 11; BMP-11 PROPERTIES
Description:Recombinant Human/Mouse/Rat Growth Differentiation Factor 11 is produced by our Mammalian expression system and the target gene encoding Asn299-Ser407 is expressed.
Accession:O95390
Formulation:Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 50% glycerol, pH 7.4.
Size:10µg/50µg/500µg/1mg
Purity:> 95%
Endotoxin:< 1 EU/µg as determined by LAL test.
Predicted Mol Massp:12.5 KDa
Apparent Mol Mass:13-20 KDa, reducing conditions
Shipping:The product is shipped on dry ice/polar packs.
Upon receipt, store it immediately at the temperature listed below.
Storage:Store at ≤-70°C, stable for 6 months after receipt.
Store at ≤-70°C, stable for 3 months under sterile conditions after opening.
Please minimize freeze-thaw cycles.
Background:Growth/differentiation factor 11(GDF-11) is a secreted protein, which belongs to the transforming growth factor beta superfamily. GDF-11 controls anterior-posterior patterning by regulating the expression of Hox genes. The secreted signal acts globally to specify positional identity along the anterior/ posterior axis during development. GDF11 has been shown to suppress neuro-genesis through a pathway similar to that of myostatin, including stopping the progenitor cell-cycle during Gphase. The similarities between GDF11 and myostatin imply a likelihood that the same regulatory mechanisms are used to control tissue size during both muscular and neural development.
NOTE:The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
