Known As:IL-15 Receptor alpha & IL-15 Fusion Protein; IL15RA&IL15; IL15RA&IL15 Complex; Interleukin-15; IL-15; IL15
PROPERTIES
Description：Recombinant Human Interleukin-15 Receptor Alpha & Interleukin-15 Fusion Protein Complex is produced by our Mammalian expression system and the target gene encoding Ile31-Asp96&Asn49-Ser162 (Asn120Asp) is expressed with a human IgG1 Fc tag at the C-terminus.
Accession：Q13261 & P40933
Formulation：Lyophilized from a 0.2 μm filtered solution of PBS, 5% Trehalose, pH 7.4.
Size：10µg/50µg/500µg/1mg
Purity：> 95%
Endotoxin：< 1 EU/µg as determined by LAL test.
Predicted Mol Mass：34.4&12.8 KDa
Apparent Mol Mass：37&17 KDa, reducing conditions
Reconstitution：Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Shipping：The product is shipped at ambient temperature.
Upon receipt, store it immediately at the temperature listed below.
Storage：Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Background：IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a
heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal
transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 binds to the alpha subunit of the IL-15RA with high affinity. IL-15 also binds to the beta and gamma chains of the IL-2 receptor, but not the alpha subunit of the IL2 receptor. IL-15 is structurally and functionally related to IL-2. Both cytokines share some subunits ofreceptors, allowing them to compete for and negatively regulate each other's activity. The number of CD8+ memory T cells is controlled by a balance between IL-15 and IL- 2. Despite their many overlapping functional properties, IL-2 and IL-15 are, in fact, quite distinct players in the immune system. IL-15 is constitutively expressed by a wide varie-ty of cell types and tissues, including monocytes, macrophages and DCs. These findings indicate that this IL-15 superagonist complex could serve as a superior immunostimulatory therapeutic agent.
NOTE:The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
