Known As: Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8; CTLA-8; IL17A; CTLA8; IL17

 PROPERTIES

Description: Recombinant Human Interleukin-17A is produced by our Mammalian expression system and the target gene encoding Gly24-Ala155 is expressed with a 6His tag at the C-terminus.

Accession: Q16552

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Size: 10µg/50µg/500µg/1mg

Purity: > 95%

Endotoxin: < 0.01 EU/µg as determined by LAL test 

Predicted Mol Mass: 15.9 KDa

Apparent Mol Mass: 15-22 KDa, reducing conditions 

Reconstitution: Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Shipping: The product is shipped at ambient temperature.

Upon receipt, store it immediately at the temperature listed below.

Storage: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.   Reconstituted protein solution can be stored at 2-8°C for 2-7 days.                                                                Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

Background: Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.

NOTE:The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.